How Priligy acts on our Body ?

Priligy is a powerful selective serotonin reuptake inhibitor. Human ejaculation is mainly mediated by sympathetic part of central nervous system.The pathway of the ejaculation starts from the spinal reflex in spinal cord, which is mediated by the brain stem.This process is initiated by a number of nuclei in the brain.Since the mechanism of action of priligy is still not clearly found by the scientists, they just presumed that the action of the drug is associated with the inhibition of the neuronal reuptake of serotonin and increases the potetiation of neurotransmitter at the pre and post synaptic receptors. So this whole process acts on the seminal vesicles, prostate, bulbo-urethral muscles and at the neck of the bladder, which is responsible for their contraction in a well co-ordinated manner to ejaculate at the right time.Thus, priligy improve and maintain a satisfactory ejaculation.

What is Therapeutic Indications of Priligy:

Priligy is used for the improvement of premature ejaculation in men between the age group of 18-64 years.Priligy is used in the patient of the groups mentioned below:

• In a patient, who has ejaculatory latency period' below or within 1 minutes.
• In patient, who has recurrent ejaculation before or just after the vaginal penetration, with a minimum stimuli.
• In patient, who has personal distress or interpersonal difficulty due to PE.
• Unable to control over ejaculation.
• In a patient, who is suffering from from PE more than six months.

Doses and method of using Priligy:

• Priligy is available in two doses, Priligy 30mg and Priligy 60mg.
• Should try to avoid continuous daily use.
• Should not use more than once in 24 hours.
• Should never start the dose with 60mg.
• Adverse effects of Priligy are higher in incidence and severity with the strength of 60mg.

What are the Methords of Administration of Priligy ?

• Priligy or dapoxetine hydrochloride is very easily absorbed and metabolised drug in the body.
• Since Priligy has a bitter taste, it is adviced to take the tablet with a full glass of water. 
• It can be taken with or without food.
• Should always be taken 1-3 hours before the physical intercourse.

What are the Contraindications of Priligy:

Priligy has the following contraindications:

• Cardiovascular diseases like:
• Ischemic heart disease.
• Heart failure.
• AV valve block.
• Any history of syncope.
• Severe depression.

Concomitant treatment under monoamine oxidase inhibitors, thiaridazone or SSRI: Always avoid taking priligy or take the advise from your doctor,if you are under concomitant treatment with these drugs or has discontinued any of these drug within 14 days.

When Should I Avoid Taking Priligy ?

• Always avoid Priligy, if you are taking any anti-fungal drug.
• Should not use Priligy, if you are a patient of central nervous system without prior discussion with your doctor.
• Talk to your health care provider if you have any blood related problem, because it can affect on your platelets.
• Priligy should not be used in women and children under the age of 18 years.

Pharmaceutical form of Priligy:

• Priligy is available in the form round, convex shaped of tablet.
• Available in the strengths as Priligy 30mg and 60mg.

What are the Side effects Associated with use of Priligy:

Priligy or dapoxetine hydrochloride has the following side effects:

• Effect on Nervous system:
• Priligy can effect on your nervous system.You may have the symptoms like:
• Dizziness
• Deadach
• Disturbance in attention
• Tremor
• Sometime syncope
• Parasthesia

Effect on eye:

• Blurred vision
• Sometime mydriasis and visual disturbance

Effect on your ear:

• Hearing problem
• Sometime vetigo and tinnitus

Effect on cardiovascular system:

• Cardiac arrest
• Increased heart rate
• Bradycardia or decreased heart rate.
• Low bklood pressure
• Hypertension
• Hot flash

Effect on respiratory system:

• Sinus congestion
• yawning

Effect on gastrointestinal system:

• Nausea and vomiting
• Upper abdominal pain
• Dry mouth
• Constipation

Effect on skin:

• Pruritis
• Cold sweat

Effect on reproductive system:

• Erectile dysfunction
• Male genital disorder
• Ejaculation failure

Other effect:

• Feeling uncomfortable
• Feeling hot

What are the Drug interaction of Priligy:

Priligy or dapoxetine hydrochloride is a potent selective serotonin reuptake inhibitor and it has the tendency to react with other drugs. So it is advised to take the instructions from your physician before you start the drug. Some of the indications are mentioned here:

• Priligy has a tendency to react with monoamine oxidase inhibitors.you may develop the symptoms if you take the drug along with monoamine oxidase inhibitors like hyperthermia,rigidity,autonomic instability, delirium and coma.
• Priligy should not be used with thioridazone. Taking priligy with thioridazone may lead to many serious complications.
• Priligy can lose its effect if you use it with PDE5 inhibitors.
• Although there are no confirmed data on the interaction of anti-haemorrhoids with priligy, but you should not forget to take your doctor's advice before you take the drug.
• Lower dose of ethanol may not impact on priligy, but the concomitant use of priligy may cause some complications like dizziness, drowsiness or altered mood.
• There is no report of the drug interaction of tomsulosin with priligy at both the strength priligy 30mg and priligy 60mg. But it is always to have a talk before taking the drug for better prevention.

Overdose of Priligy:

According to the clinical pharmacological research, there no overdose of Priligy upto the dose of 240mg (if it is taken in 2-3 divided doses). But sometimes, you may have some mild problem like nausea, vomiting, tremor, dizziness or increased heart rate.

Storage of the Priligy:

Priligy or dapoxetine hydrochloride is available in the form of tablets which comes in a tight container. Priligy should be kept in a dry and cool place. It can be kept in refrigerator and out of reach of children, but should not freez it.Always throw out the expired and unused tablets of Priligy.

What are the Precautions and warnings of Priligy:

Priligy is a strong SSRI product, so it is better to take the drug according to your doctor's instruction. Some of the precautions taken during consuming priligy are mentioned below:

• Sometimes the patient may have syncope after taking priligy at a higher strength. So always take your doctor's suggestion before you take the drug.
• Never take Priligy in combination with the drugs like lysergics, diethylamiode, or ketamine as it can lead some complications like dizziness, arrhythmias or hyperthermia. So you should always avoid driving vehicles, any surgical procedure or night outing after taking priligy.
• You should always avoid taking priligy if you are suffering from orthosthetic hypertension. So it is better to talk with your physician if you have this problem.
• Always inform your doctor if you are taking some antibiotics and anti-hypertensives like clarithromycin, fluconazole, verapamil, deltiazin or erythromycin to avoid any complication.
• Priligy or dapoxetine has a power to reduce the threshold of epilepsy. So always avoid the use of priligy if you are taking any anti-epilectinc drug.
• Studies say that chronic use of priligy or dapoxetine hydrochloride may increase the suicidal thinking below the age of 18 years compared to its acute use. So always be careful in taking priligy and take help from your health care provider if you are suffering depression, anxiety while you are taking priligy.
• You should always inform your doctor if you are experiencing any eye problem because priligy has some side effects on the eyes like blurred vision, mydriasis or 
• glaucoma.
• Always avoid taking prigily if you have any haemorrhagic (blood) diseases like anaemia, polycythemia, sickle cell anemia because it can affect your platelets.