Sibelium or Flunarizine can significantly decrease the attack the frequency and the intensity of headache. It can be used in both adults and children. This medication is available in the form of tablet, at the strength of 5mg and 10mg. This medication is very popular because it is very easily available and cost effective.

How does Sibelium work in migraine?

In migraine it works as following:

• It stops the release of norepinephrine through alpha-2 agonism, which decreasesthe activity of central catecholaminergic.
• It stops the function of 5-HT1A and 5-HT2Breceptors and reduces the excitability of neurons.
• It blocks the synthesis of nitric oxide by action of alpha2-agonist and prevents the production of nitric oxide. Thus it reduces the migraine, because it is believed that Nitric oxide is the major pathway for producing migraine headache.
• It alsodecreases the functions of neurons and inactivates the excitatory glutamate receptors.

What are the indications of Sibelium?

Sibelium is a calcium channel blocker and it is used for the treatment of the following conditions:

• Migraine
• Vertigo
• Occlusive peripheral vascular disease
• Adjuvant therapy of epilepsy.   

What are the contraindications?

• In a patient who has a history of depression
• History of pre-existing extra pyramidal diseases
• Hypersensitivity to any medication.

What is the dose of sibelium?

The most recommended dose of this medication is 10mg, taken once in a day at bed time. The dose can be reduced to 5 mg depending on the requirement.

What is the method of taking this medication?

This medication is taken at bed time, with or without a meal.

How should you store this medication?

You should store this medication in room temperature, in a cool and dry place. Keep this medication out of reach of children.

What are the side effects of sibelium?

The common side effects are:

• Drowsiness
• Depression.

Serious side effects are:

Gastrointestinal effects:

• Nausea
• Vomiting
• Stomach pain
• Acidity

Central nervous system effects:

• Vertigo
• Sleep disturbance
• Dizziness

Other side effects are:

• Weakness
• Skin rashes
• Dry mouth
• Muscle pain

What are the precautions of Sibelium?

• Always ask advice from your doctor before taking this drug if you are suffering from any diseases linked to kidney or liver.
• Caution should be taken if you are a patient of cardiac disease.
• Ask emergency medical care if you catch any eye problem while taking this medication.
• Do not take this medication if you are pregnant or lactating.
• This medication should be used in elderly people and in children only under the guidance of the physician.